A continuación, se describe el caso de un hombre de 37 años con diarrea crónica de 6 meses de evolución y frecuentes hospitalizaciones por trastornos hidroelectrolíticos, generados por hipocalemia severa y lesión renal aguda por deshidratación. Los vipomas se manifiestan con diarrea crónica de características secretoras, que usualmente conducen a trastornos hidroelectrolíticos e incluso a complicaciones serias asociadas como la falla renal. Las pNEN funcionales secretan hormonas como la gastrina, la insulina y el glucagón y otras menos frecuentes como el péptido intestinal vasoactivo (PIV), por lo que sus características sindromáticas dependen del péptido secretado. Las NEN de localización pancreática (pNEN) pueden ser funcionales o no funcionales. Las neoplasias neuroendocrinas ( Neuroendocrine Neoplasms, NEN) constituyen un grupo heterogéneo de neoplasias poco frecuentes, que se originan en las células endocrinas, con la capacidad de secretar aminas y polipéptidos hormonales. Keywords: Chronic diarrhea secretory diarrhea neuroendocrine tumor vipoma They have been treated surgically intervention with favorable clinical results and complete remission of symptoms.
More studies of PNETS are being published. Empirical therapy with Octreotide was begun to control diarrhea and correct the hydroelectrolytic disorder. After multiple studies, a diagnosis of secretory diarrhea due to a VIP secretory functional NET was considered. This article describes the case of a 37-year-old man who had suffered chronic diarrhea with frequent hospitalization for hydroelectrolytic disorders for six months due to severe hypokalemia and acute renal damage due to dehydration. Vipomas are characterized by chronic diarrhea of secretory characteristics that usually lead to hydroelectrolytic disorders and can lead to serious complications associated with renal failure. Their characteristics depend on the peptide secreted. Functional PNETs secrete common hormones such as gastrin, insulin and glucagon and much less frequent hormones such as vasoactive intestinal peptide (VIP). Pancreatic neuroendocrine tumors (PNETs) can be functional or non-functional. Neuroendocrine tumors (NETs) are a heterogeneous group of rare neoplasms that originate in endocrine cells with the ability to secrete amines and hormonal polypeptides.
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